个人简介
段旭君，电子科技大学生命科学与技术学院教授，博士生导师。国家自然科学基金优青（2023）;国际脑图谱年会（OHBM）Keynote Speaker（2023）；中国图象图形学学会石青云女科学家奖（2024）; 科技部重点研发计划青年科学家项目负责人（2024）；四川省杰出青年基金（2024）。中国认知科学学会 儿童脑智发展与健康专业委员会 副主任委员;中国遗传学会 行为遗传分会 委员;中国神经科学学会 儿童认知与脑功能障碍分会 委员;中国自动化学会 智能健康与生物信息专委会 委员;中国图象图形学学会 视觉认知与计算专委会 委员;四川省神经科学学会 理事；国际脑影像期刊《Imaging Neuroscience》编委。
主要研究领域为孤独症脑影像，在孤独症脑动态网络成像、多模态融合成像、脑成像引导的神经调控等方面开展了一系列研究，建立了“评估-干预-成像”的孤独症智能诊疗平台，并开展临床应用，发起并成立中国孤独症脑影像联盟。相关研究成果以第一/通讯作者发表在PNAS, Biological Psychiatry，Science Bulletin，eLife等期刊；主持5项国家自然科学基金项目和1项科技部重点研发计划青年科学家项目（均为孤独症脑影像领域）。
主持或参与的科研项目
国家重点研发计划青年科学家项目，2024YFF0509100，孤独症仿生光声刺激的神经反馈与调控研究，2024/12-2029/11，400万元，在研，主持
国家自然科学基金优秀青年基金，82322035，孤独症脑成像，2024/01-2027/12, 200万元，主持
广东省重点领域研发计划，孤独症早期诊断及干预技术研究，2023B0303020001，2023/01-2025/12，500万元，在研，主持
国家自然科学基金面上项目，62273076，多源融合的孤独症神经机制建模与辅助诊疗算法研究，2023/01-2026/12，53万元，在研，主持
国家自然科学基金面上项目，81871432，经颅磁刺激干预儿童孤独症的多模态影像学神经机制研究，2019/01-2022/12, 56万元，已结题，主持
国家自然科学基金面上项目，61673089，儿童孤独症早期干预的脑可塑性多模态磁共振研究，2017/01-2020/12, 62万元，已结题，主持
获奖
1.中国图象图形学学会石青云女科学家奖，段旭君，2024年，排名（1/1）
2. 磁共振脑网络成像新方法及其对癫痫脑机制的研究，四川省科学技术进步奖，自然科学类一等奖，2018，排名（5/5）
3.癫痫多模态磁共振成像新技术临床应用研究，中华人民共和国教育部，科技进步一等奖2013年，排名（17/18）
专利
1.段旭君，李镭，肖金明，陈华富，基于磁共振成像的个体空间经颅磁刺激精准定位导航的方法。专利号：ZL 2022 1 0373878.4
2.陈彦弛，段旭君，廖伟，刘宏宇，雷鑫峰，王润诗。一种基于杏仁核功能环路介导的重复经颅磁刺激影像导航的方法。2018，申请号：201810125830.5
3.廖伟，段旭君，陈华富。一种基于fMRI探测动态脑自发活动的数据方法。专利号：ZL 2016 1 0524807.4
软件著作权
1.段旭君，单晓龙，肖金明，何长春，陈华富。孤独症眼动评估软件。登记号：2020SR0295320。
2.龙治良，段旭君，廖伟，陈华富。基于神经影像亚分类软件。登记号：2020SR0347621。
3.陈华富，陈恒，何长春，郭肖楠，卢凤梅，段旭君。双聚类大脑皮下脑区亚区定位软件。登记号：2019SR0772808。
4.段旭君，李镭，陈华富，功能环路介导的深部脑刺激定位软件。登记号：2023SR0280008.
代表性论文：
2025
[1]Xinyue Huang, Weixing Zhao, Rui Feng, Yuanyue Zhou, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Yu Feng, Yating Ming, Jing Cao, Xiaodong Kang, Lijie Wu, Huafu Chen*,Xujun Duan*. Linking gut microbiome profiles and white matter integrity to social behavior in young autistic children: from the perspective of individual variation.Science Bulletin, 2025, in press
[2]Jinming Xiao#,Yating Ming#,Lei Li#,Xinyue Huang,Yuanyue Zhou,Jianjun Ou,Juan Kou,Rui Feng,Rui Ma,Qingyu Zheng,Xiaolong Shan,Yao Meng,Wei Liao,Yingli Zhang,Ting Wang,Yangying Kuang,Jing Cao,Shijun Li,Hua Lai,Jia Chen,Qi Wang,Xiaoli Dong,Xiaodong Kang,Huafu Chen*,Vinod Menon*,Xujun Duan*. Personalized theta-burst stimulation enhances social skills in young minimally verbal children with autism: a double-blind randomized controlled trial.Biological Psychiatry,2025,doi: 10.1016/j.biopsych.2025.01.002.
[3]Xujun Duan*, Xiaolong Shan, Lucina Q. Uddin, Huafu Chen*.The future of disentangling the heterogeneity of autism with neuroimaging studies.Biological Psychiatry,Volume 97, Issue 5P428-438March 01, 2025https://doi.org/10.1016/j.biopsych.2024.08.008
[4]Lei Li, Jinming Xiao, Weixing Zhao, Qingyu Zheng, Xinyue Huang, Xiaolong Shan, Yating Ming, Peng Wang, Zhen Wu, Huafu Chen*, Vinod Menon*,Xujun Duan*. Mother-child dyadic interactions shape children’s social brain and theory of mind.eLife,2025,https://doi.org/10.7554/eLife.103017.1
[5]Lei Li, Xinyue Huang, Qingyu Zheng, Jinming Xiao, Xiaolong Shan, Huafu Chen*,Xujun Duan*. Similarity or complementarity? Understanding marital relationships in terms of sexual dimorphism in brain morphometry and gender roles.NeuroImage, 2025/1/1, 305: 120974
[6]Lei Li, Xinyue Huang, Qingyu Zheng, Jinming Xiao, Xiaolong Shan, Huafu Chen*,Xujun Duan*. Similar trajectories of psychological states predict marital satisfaction.Imaging Neuroscience.2025/1/22.
2024
[1]Weihua Zhao*, Keith M. Kendrick,Xujun Duan*. Challenges and prospects in the autism spectrum disorder field.Medicine Plus, 2024, 1, 100045
[2] Yu Feng, Xinyue Huang, Weixin Zhao, Yating Ming , Yuanyue Zhou, Rui Feng Jinming Xiao, Xiaolong Shan, Xiaodong Kang,Xujun Duan*, Huafu Chen*. Association among internalizing problems, white matter integrity, and social difficulties in children with autism spectrum disorder.Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 135, 20 December 2024, 111109
[3]Xiaolong Shan, · Peng Wang, · Qing Yin,· Youyi Li, · Xiaotian Wang, · Yu Feng,· Jinming Xiao, · Lei Li, ·Xinyue Huang, · Huafu Chen, · Xujun Duan, Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles,European Child & Adolescent Psychiatry, 2024, Accepted
[4]Xinyue Huang, Leying Gao, Jiming Xiao, Lei Li, Xiaolong Shan, Huafu Chen, Xiaoqian Chai*,Xujun Duan*, Family environment modulates linkage of transdiagnostic psychiatric phenotypes and dissociable brain features in the developing brain,Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2024, Accepted
[5]单晓龙，陈华富，段旭君*，孤独症谱系障碍多模态磁共振脑影像模式识别。心理科学进展，2024，vol. 32, No. 7
[6]Zhao W, Li L, Yang X, Wang X, Kou J, Chen J, Chen H, Wang Q, Duan X. Brain development of a school-aged boy with autism spectrum condition talented in arithmetic: a case report.Psychoradiology. 2024 Apr 18;4:kkae008. doi: 10.1093/psyrad/kkae008.
2023
[1]Xiaolong Shan, Lucina Q. Uddin, Rui Ma, Pengfei Xu, Jinming Xiao, Lei Li, Xinyue Huang, Yu Feng, Changchun He, Huafu Chen*,Xujun Duan*. Disentangling the individual-shared and individual-specific subspace of altered brain functional connectivity in autism spectrum disorder,Biological Psychiatry. DOI: 10.1016/j.biopsych.2023.09.012
[2]Xinyue Huang, Yating Ming, Weixing Zhao, Rui Feng, Yuanyue Zhou, Lijie Wu, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Jing Cao, Xiaodong Kang, Huafu Chen*,Xujun Duan*. Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain,Molecular Autism, 2023,14:41.
[3]郑清予，李镭，肖金明，陈华富，段旭君。孤独症谱系障碍默认网络与任务正激活网络交互的共激活模式研究，《中华精神科杂志》，2023,56 (4) 56 (4): 284-291，DOI: 10.3760/cma.j.cn113661-20221009-00278
2022
[1]JinmingXiao, Lucina Q.Uddin, YaoMeng, LeiLi, LeyingGao, XiaolongShan, XinyueHuang, WeiLiao, HuafuChen*,XujunDuan*. A spatio-temporal decomposition framework for dynamic functional connectivity in the human brain.NeuroImage,2022, doi.org/10.1016/j.neuroimage.2022.119618
[2] Lei Li, Xinyue Huang, Jinming Xiao, Qingyu Zheng, Xiaolong Shan, Changchun He, Wei Liao, Huafu Chen*, Vinod Menon*,Xujun Duan*. Neural synchronization predicts marital satisfaction.Proc. Natl. Acad. Sci. U.S.A., 2022, 119 (34), e2202515119.
[3]Lei Li#, Xiaoran Su#, Qingyu Zheng, Jinming Xiao, XinYue Huang, Wan Chen, Kaihua Yang, Lei Nie, Xin Yang, Huafu Chen*, Shengli Shi*,Xujun Duan*.Cofluctuation analysis reveals aberrant default mode network patterns in adolescents and youths with autism spectrum disorder.Human Brain Mapping, 2022,DOI: 10.1002/hbm.25986.
[4] Xiaolong Shan, Lucina Q. Uddin, Jinming Xiao, Changchun He, Zihan Ling, Lei Li, Xinyue Huang, Huafu Chen,Xujun Duan*. Mapping the heterogeneous brain structural phenotype of autsim spectrum disorder using the normative model.Biological Psychiatry.2022, 91:967–976.
2021
[1]Xinyue Huang, Lei Li, Zihan Ling, Leying Gao, Huafu Chen,Xujun Duan*. Gut microbiome diversity mediates the association between right dorsolateral prefrontal cortex and anxiety level.Brain Image and Behavior,2021, Accepted.
[2]Heng Chen#, Fengmei Lu#, Fengmei Lu, Yajing Pang, Yajing Pang, Shaoqiang Han,Xujun Duan*, Huafu Chen*. Dimensional Analysis of Atypical Functional Connectivity of Major Depression Disorder and Bipolar Disorder.Cerebral Cortex, 2021, in press.https://doi.org/10.1093/cercor/bhab296
[3]Changchun He, Jesus M. Cortes, Xiaodong Kang, Jing Cao, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Jinming Xiao, Xiaolong shan, Rui Feng, Huafu Chen,Xujun Duan*. Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder.Human Brain Mapping, 2021,42(10):3282-3294.
[4]Jinming Xiao, Huafu Chen*, Xiaolong Shan, Changchun He, Ya Li, Xiaonan Guo, Heng Chen, Wei Liao, Lucina Q. Uddin*,Xujun Duan*. Linked social–communication dimensions and connectivity in functional brain networks in autism spectrum disorder.Cerebral Cortex, 2021,31(8):3899-3910. DOI: 10.1093/cercor/bhab057
[5]Xiaonan Guo,Xujun Duan*,John Suckling, JiaWang, Xiaodong Kang, Heng Chen, Bharat B. Biswal, Jing Cao, Changchun He, Jinming Xiao, Xinyue Huang, Runshi Wang, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Jingping Zhao, Lijie Wu* and Huafu Chen*, Mapping progressive gray matter alterations in early childhood autistic brain.Cerebral Cortex, 2021，31(3):1500-1510.
[6]Xujun Duan#, Changchun He#, Jianjun Ou, Runshi Wang, Jinming Xiao, Lei Li, Renrong Wu, Yan Zhang*, Jingping Zhao*, Huafu Chen*.Reduced hippocampal volume and its relationship with verbal memory and negative symptoms in treatment-naive first-episode adolescent-onset schizophrenia.Schizophrenia Bulletin,2021, 47(1): 64-74.
2020
[7]Lei Li, Changchun He, Taorong Jian, Xiaonan Guo, Jinming Xiao, Ya Li, Heng Chen, Xiaodong Kang, Huafu Chen,Xujun Duan*.Attenuated link between the medial prefrontal cortex and the amygdala in children with autism spectrum disorder: evidence from effective connectivity within the “social brain”.Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020,111:110147. doi: 10.1016/j.pnpbp.2020.110147
[8]Xujun Duan#, Maolin Hu#, Xinyue Huang, Chan Su, Xiaofen Zong, Xia Dong, Changchun He, Jinming Xiao, Haoru Li, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effect of risperidone monotherapy on dynamic functional connectivity of insular subdivisions in treatment-naive, first-episode schizophrenia.Schizophrenia Bulletin,2020, 46(3): 650-660.
[9]Changchun He, Huafu Chen*, Lucina Q. Uddin, Asier Erramuzpe, Paolo Bonifazi, Xiaonan Guo, Jinming Xiao, Heng Chen, Xinyue Huang, Lei Li, Wei Sheng, Wei Liao, Jesus M. Cortes*,Xujun Duan*. Structure-Function Connectomics Reveals Aberrant Developmental Trajectory Occurring at Pre-adolescence in the Autistic Brain.Cerebral Cortex, 2020, 30（9）：5028-5037.
[10]Xiaonan Guo,Xujun Duan*, Heng Chen, Changchun He, Jinming Xiao, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Huafu Chen*. Altered inter- and intrahemispheric functional connectivity dynamics in autistic children.Human Brain Mapping, 2020, 41 (2), 419-428
[11]Xujun Duan, Runshi Wang, Jinming Xiao, Ya Li, Xinyue Huang, Xiaonan Guo, Jing Cao, Liyao He, Changchun He, Zihan Ling, Xiaolong Shan, Heng Chen, Xiaodong Kang*, Huafu Chen*. Subcortical structural covariance in young children with autism spectrum disorder.Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 99:109874.DOI: 10.1016/j.pnpbp.2020.109874
[12]Xujun Duan#, Maolin Hu#, Xinyue Huang, Xia Dong, Xiaofen Zong, Changchun He, Jinming Xiao, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effects of risperidone monotherapy on the default-mode network in antipsychotic-naïve first-episode schizophrenia: Posteromedial cortex heterogeneity and relationship with the symptom improvements.Schizophrenia Research, 2020,218:201-208.DOI: 10.1016/j.schres.2020.01.001
2019
[13] Heng Chen, Lucina Q. Uddin, Xiaonan Guo, Jia Wang, Xiaomin Wang,Xujun Duan*, Huafu Chen*. Parsing brain structural heterogeneity in autism spectrum disorder reveals distinct clinical subtypes.Human Brain Mapping, 2019, 40(2): 628-637.
[14] Xiaonan Guo,Xujun Duan*, John Suckling, Heng Chen, Wei Liao, Qian Cui, Huafu Chen*. Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder,Human Brain Mapping, 2019, 40(4):1264-1275.
2018
[15] Heng Chen#, Jia Wang#, Lucina Q. Uddin, Xiaomin Wang, Xiaonan Guo, Fengmei Lu.Xujun Duan*, Lijie Wu*, Huafu Chen*. Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder,Autism Research. 2018，11（2）：1643-1652.
[16] Changchun He, Yanchi Chen, Taorong Jian, Heng Chen, Xiaonan Guo, Jia Wang, Lijie Wu*, Huafu Chen*, andXujun Duan*. Dynamic functional connectivity analysis reveals decreased variability of the default-mode network in developing autistic brain.Autism Research, 2018. 11(11): 1479-1493.
教育经历
电子科技大学 工学学士学位
电子科技大学 工学博士学位
工作经历
2021.1-至今
电子科技大学生命科学与技术学院 | 研究员 | 研究员
2014.7-至今
电子科技大学生命科学与技术学院 | 副教授
2013.7-2014.6
电子科技大学生命科学与技术学院 | 讲师